BPC-157, also known as Body Protection Compound 157, is a synthetic peptide composed of 15 amino acids originally derived from a naturally occurring protein fragment in human gastric juice. Its amino acid sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. The peptide is highly stable in gastric juice, allowing for potential oral bioavailability, and can also be administered via injection in preclinical studies.
BPC-157 promotes healing primarily by activating the VEGF receptor 2 (VEGFR2) pathway, which stimulates angiogenesis (formation of new blood vessels) and tissue repair. It also interacts with multiple biological pathways, providing cytoprotective, neuroprotective, and anti-inflammatory effects. Animal studies have shown benefits in musculoskeletal injuries, tendon and ligament repair, bone healing, and nerve regeneration.
